Prolonged adaptability of highly qualified athletes to training stresses, studied by longitudinal metabolomic analysis of biofluids
Ключевые слова:
training loads, long-term adaptation, metabolic profiling, functional state, qualified athletes, mechanisms of adaptation processes.Аннотация
Objective of the study is to determine the feasibility of longitudinal metabolome analysis of biological samples from elite athletes to identify previously unknown and highly sensitive metabolic processes associated with long-term adaptation to intense training.
Methods and structure of the study. To identify metabolic pathways associated with long-term adaptation to training in elite athletes, a computerized search and analysis of relevant scientific publications describing the capabilities of longitudinal metabolomic analysis of biological samples was performed. The search was conducted in the electronic scientific citation databases PubMed, Scopus and Web of Science to identify relevant studies.
Results and conclusions. Careful planning of the pre-analytical phase (including selection of study participants, definition of the analyzed sample, choice of methodology and approach to profiling) is the key to successful longitudinal metabolomic analysis of biological fluids in professional athletes involved in a long-term training cycle. Using such opportunities allows identifying significant shifts in the functioning of the physiological systems of the body of the trainee (endocrine, cardiovascular, oxygen transport system, energy metabolism at the cellular level), which are reflected in the metabolomic profile of the studied biological fluid.
Systematic multi-month training forms a specific phenotype of a highly qualified athlete, determined by his individual ability to adapt and having a unique metabolomic expression. Longitudinal metabolomic analysis of biological fluids provides information necessary for an in-depth study of the mechanisms of long-term adaptive changes occurring in the body of professional athletes.
Библиографические ссылки
Bondzhovanni T., Lakome M., Fanos V. Metabolomika u sportsmenov, zanimayushhihsya komandnymi vidami sporta: sovremennye znaniya, problemy i perspektivy na budushhee. Proteomy. 2022. No. 10(3). P. 27.
Bragaczci N.L., Kajvan K., Chauachi A. Na puti k sportomike: perehod ot sportivnoy genomiki k sportivnoy postgenomike i metabolomike. Perspektivy, vyzovy i perspektivy na budushhee. Specialist po sportivnoy fiziologii. 2020. No. 15(9). Pp. 1201–1202.
Gonsales Dzh.R., Kaseres A., Ferrer E. Prognozirovanie travm u elitnyh futbolistok s pomoshhyu globalnoy sistemy pozicionirovaniya i dannyh multiomiki. Int. J. Sports Physiol. 2024. No. 19(7). Pp. 661–669.
Dzhaguri A., Al Tani A.A., Elrajess M.A. Metabolizm fizicheskih uprazhneniy: vliyanie na zdorove i rabotosposobnost. Metabolity. 2023. No. 13(6). P. 694.
Horamipur K., Sandbakk O., Keshteli A.X. Metabolomika v fizicheskih uprazhneniyah i sporte: sistematicheskiy obzor. Sportivnaya medicina. 2022. No. 52(3). Pp. 547–583.
Ksiazek A., Zagrodna A., Lombardi G. Sezonnye izmeneniya sootnosheniya svobodnogo 25-(OH)D i metabolitov vitamina D i ih svyaz s markerami psihofizicheskogo stressa u professionalnyh futbolistov muzhskogo pola. Physiol. 2023. No. 14:1258678.
Luti S., Militello R., Pinto G. Postoyannye trenirovki vyzyvayut metabolicheskuyu i proteomnuyu reakciyu u basketbolistov muzhskogo i zhenskogo pola: izmeneniya v slyunootdeleniy vo vremya sezonnyh trenirovok. Zdravoohranenie (Bazel). 2023. No. 11(2). P. 241.
Parstorfer M., Poshhet G., Kronshtejner D. Celenapravlennaya metabolomika v sporte vysshih dostizheniy: razlichiya mezhdu metabolicheskim profilem v sostoyanii pokoya u sportsmenov, treniruyushhihsya na vynoslivost i silu, po sravneniyu s liczami, vedushhimi malopodvizhnyy obraz zhizni, v techenie trenirovochnogo goda. Metabolity. 2023. No. 13(7). P. 833.
Pinto G., Militello R., Amoresano A. Vzaimosvyaz mezhdu polom i adaptaciey k fizicheskim nagruzkam u molodyh sportsmenov: pilotnoe issledovanie. Zdravoohranenie (Bazel). 2022. No. 10(2). P. 358.
Ci S., Li X., Yu Dzh. Nauchnye dostizheniya v oblasti primeneniya metabolomiki v nauke o fizicheskih uprazhneniyah. Fiziol. 2024. No. 14:1332104.
Kvint G., Reche X., Sandzhuan-Xerraez Dzh.D. Metabolomnyy analiz mochi dlya monitoringa vnutrenney nagruzki u professionalnyh futbolistov. Metabolomika. 2020. No. 16(4). P. 45.
Rodas G., Ferrer E`., Reche X. Celenapravlennyy metabolicheskiy analiz futbolistov i ego svyaz s nagruzkoy igrokov: sravnenie profiley zhenshhin i muzhchin. Fiziol. 2022. No. 13:923608.
Rodas G., Ferrer E., Sandzhuan Dzh. D. UPLC-MS i mnogomernyy analiz vyyavlyayut adaptaciyu metabolicheskih putey k trenirovkam u professionalnyh futbolistov. Talanta. 2025. No. 291:127893.
Shranner D., Kastenmyuller G., Shonfelder M. Izmeneniya koncentracii metabolitov v organizme cheloveka posle fizicheskoy nagruzki: sistematicheskiy obzor issledovaniy po metabolomike fizicheskih nagruzok. Sportivnaya medicina. 2020. No. 6(1). P. 11.
Vike N.L., Bari S., Steciv K. Metabolicheskaya reakciya na uchastie v studencheskom futbole: analiz do i posle sezona. Sci Rep. 2022. No. 12(1):3091.
Дополнительные файлы
Опубликован
Версии
- 2025-09-08 (4)
- 2025-09-07 (3)
- 2025-09-06 (2)
- 2025-09-06 (1)
Как цитировать
Выпуск
Раздел
Лицензия
Copyright (c) 2025 Theory and Practice of Physical Culture
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
